Pylori associated gastritis

Helicobacter Pylori associated continuing gastritis resulting in duodenal ulceration or Peptic ulcer Dsease. Gastric suffer at night and when hungry ulcer Is duodenal as the pyloric sphincter is open. Single punched-out lesion In the duodenum where of peptic ulcers occur. H. PyIori most common grow of peptic ulcers. Erythematous stomach and history of dyspepsia This indicates inflammation associated with chronic gastritis result of long term hyperacidity in the stomach and duodenum. Patient was a smoker. Smoking reduces alliance flow and Impedes healing of the epithelium and mucosa.Presence of curved and spiral-shaped bacilli in spite of appearance the superflclal mucosa of the antrum (no mention of the body of stomach) indicates H. Pylori infection. This induces hyperacidity, increasing the risk of duodenal and stomachic ulceration (H. PyIori in of people with peptic ulcers). Large numbers of neutrophils in the lamina propria extending into the epithelium forming pit abscesses and large numbers of plasma and lyrnphocytic cells with germinal centres Infiltrating the lamina proprla Is characteristic of chronic gastritis as the body mounts an Immune response.Gastric epithelium regenerates rapidly, replacing damage cells. Extensive blood supply to mucosa. Predisposing factors H. Pylori infection 80% of peptic ulcers Smoking- reduces blood flow, impedes healing. High-dose corticosteroid use (inhibits prostaglandin production) More commonly seen in people with alcoholic beverage cirrhosis (alcohol stimulates gastric acid secretion), chronic obstructive pulmonary infirmity (reduces 02 blood perfusion), chronic renal failure and hyperparathyroidism (promote gastrin secretion). 3) Natural history o Peptic ulcers usually heal within weeks but reoccur within months(75% by and by one year) unless treated.Longer healing indicates quicker reoccurrence unless stimulus is removed. o A seven-day period of symptoms before presentation is associated with poorer respons e to treatment. Complications o smaller vessels- anemia o large vessel- malema or haematemesis o major artery life threatening. o Perforation- spillage of GIT contents into peritoneum leads to infection (peritonitis) o Obstruction- pyloric stenosis from continuous healing and scarring near pyloric valve. (10% of patients) Leads to bit glass deformity of stomach. o Carcinoma development- (1% of gastric ulcers, never duodenal ulcers)